Much as I agree with the 1911/.45 analysis posted here, I'm a Glock fan. Our primary defense weapon is a Model 23 (.40 S&W).
Like a C-Dory, it's simple, rugged, and reliable. With the exception of one batch of bad loads (insufficient powder, action wouldn't cycle), I've fired thousands of rounds through mine, and never had a misfeed, misfire or mechanical breakdown. It spits out everything perfectly, from cheap low powered FMJ reloads, to stiffly loaded HP defense loads.
I'm also a big fan of the lack of an external safety on a Glock. The best safety on any weapon is the one between your ears, and while safe handling of any firearm is firmly ingrained in my head, I don't shoot as often as I used to. In a time of need, I'm not confident dealing with an external safety would be second nature to me, as it would be to those of you who shoot regularly. I just want to pick the thing up and be ready to shoot, keeping in mind the generic safety precautions applicable to any make or model of firearm.
And IMO, therein lies one of the deciding factors in the ages-old 1911 vs. Glock debate. If you rarely shoot or carry, but want something reliable and simple to use, there's a strong case to be made for the Glock. Many will suggest revolvers for folks in this situation, but I seem to be in the minority here...don't like them for defense weapons. I want my first shot to be quick and count, and I consider cocking the hammer or relying on a double-action trigger pull for the first shot to be a drawback.
If you are a more accomplished/regular shooter, the choice becomes more involved, the case is stronger for a 1911, and typically boils down to one of personal preference.
Setting aside handgun preference, once you've made up your mind what to get,
here's a handgun safe manufacturer that is top notch. The construction is the best I've seen, both from a quality and functional standpoint. The use of a mechanical Simplex lock requires no batteries, and can easily be opened in the dark with a little practice. I've got one installed in my home, and will probably get one for the boat some day. If you install them cross-bolted in a corner, they are very tough to forcibly remove with a prybar.