Yes, the center window on the CD 22 pilot house is like a hatch and opens foreward.
If the AC unit is the correct size (or any size if you can use short pieces of door skin plywood/duct tape etc) and direct the cool in--and hot out.
We tried using the portable airconditioners on other boats in the past, and the problems involved with taking it in and out of the area, storage etc made it so difficult for us, we abandoned this type of use.
We have also made "ducts" out of door skins, plastic, cardboard etc for temporary air conditioning thru top opening hatches. Definately keep the air conditioning unit level!
The reason we used an RV air conditioner: it sits in place without taking any cabin space or restricting vision. It does cost about $400 more than the Wal Mart Fedders (we use one of the Wal mart Fedders in our Road Trek--there it is vented out of the back of the top of the RV.
I have talked to several who have used the ice chest--yes it will cool, but not near what a regular air conditioner--but most folks end up using a quality fan thru a hatch or going with a real air conditioner. To look at it scientifically: to raise or lower the temperature of 1 lb. of ice by 1°F, it takes only 0.5 BTU. However, to change 1 lb. of water into ice, we have to remove 144 BTUs of energy. Conversely, to change 1 lb. of ice into water, we have to add 144 BTUs. so to get 5000 btu of cooling you will have to melt 35 lbs of ice an hour! That is a lot of ice! Yep, I tryed that in college when we didn't have AC--and 100 lbs of ice got me thru a night of cramming for finals.
On the other hand, we just use a "endless breeze" or Wal mart 12 volt fan on a hatch once the sun goes down to keep the bunk area livable after we go to sleep, even in the Florida summer.