Ah, that Les cuts to the chase. I've heard a lot of people say that the enclosed head is the difference between the 25 and the 22... so much more. The elbow room in the 25 is quite generous compared to the 22. My wife and I can pass each other in the aisle. If she is working at the galley, I can get around her. Think that doesn't make much difference? Try spending extended time on it. The v-berth is over a foot wider. More storage. Shelves in the v-berth. More room at the dinette. The fridge (one can be added to a 22) means there's no "hunt for ice. More room in the cockpit. 100 gallons of fuel vs 38, but the heavier 25 uses more fuel. The "real estate" on the bow is much more - easier for anchor handling or tying to a mooring. Oh, and there's an enclosed head; ours has the Sealand toilet which uses fresh water. And a shower. With hot water. Pressure water. Room for a microwave. An electrical system (30 amp). The boat feels more stable underway and at anchor.
Ours weighed in at 8700 pounds on the trailer, with a light fuel load, full water, and cruising equipped, when we checked it on a certified scale. We tow with a diesel pickup.
I have no doubt that we would not do the extended cruising if we had a 22, but it certainly works well for others. It's not a matter of what you can do without, but rather where your comfort level is... if you and your wife don't feel like you are being deprived of amenities, you will spend more time on the boat.
I was absolutely convinced we wanted a 22 before we ever saw both boats side by side. When we saw the boats at the Seattle Boat Show, we went back and forth. Well, I went back and forth. The Blonde said, "We want this one (the 25)," and she was right. It is the right boat for the way we use it.
While we are together on the boat almost all the time, I can singlehand launch and retrieve... anchor and dock... go to the fuel dock. When we are home, I do take the boat out by myself quite a bit. When we put the boat in together, she usually handles lines while I back the boat in. When we retrieve, she usually backs the trailer in while I drive the boat onto the trailer. It's much faster when we work together. I don't see that any of that would be easier if the boat were smaller.
Three feet doesn't sound like much, but the increase of volume (usable space) in the cabin is dramatic. There's an additional foot of beam. I am not trying to convince anyone one way or the other... we looked at all of the above when making our choice, and it fits us. Bill and El have taken 5 people on extended cruises on their 22 and wouldn't have it any other way. I can't imagine all that time with 5 people on any small boat, but we consider ours a 2 person cruiser, that can seat or feed four on occasion.
Good luck with your decisions. This comes up frequently here, and most people will defend their buying decision. It all comes down to how you will use the boat, how much personal space you require, and what your budget will allow. The porta-potty vs an installed toilet is really much less of an issue for us; we've had both on previous boats, and they both work just fine. If an enclosed head is a decision-maker for you, then your choice is simple.
One other perspective: would you stay in a motel that didn't have a shower? Does your home have a separate bathroom? I think it IS an important factor, but for us, it wasn't the main factor in choosing the 25.
Best wishes,
Jim B.