Interesting discussion on mileage, and of course the original question on the ride of a 22 vs 25 (and 26).
I've owned my boat since new, and have been through many varied conditions, as have others, from zero chop to 3-5 ft and with up to 12 ft rollers. I have twin Yami F80's and permatrims which I use religiously. If ONE pound occurs due to a wave, I either 1) Slow down 1-2 nmph, or 2) Drop the bow a bit with the trim tabs. I don't like pounding, not many do, and I love the ride of my boat in most all conditions except heading into short, steep chop like when the wind and current are opposite, falling off the other side of the wave isn't pleasant! I've also found while boating in the same conditions with other CD22's, I can go 2-4 nmph faster in following seas, about the same heading into the seas.
Oh, and I have my engines set to about -15 deg (with permatrims) when they are bottomed out. Before the permatrims I got my best speed vs rpms with the engines all the way down on the mount, no bolt to stop them, and adjusted the trim with my oversized trim tabs (about 50% larger than factory in 2003).
Another data point on gas mileage. I calculate it with GPS distance divided by filling the tank full over that distance (sometimes takes several trips/distances before I fill it). I have twin engines, slightly heavier than a single, but not much different than a single with a kicker. I also don't have a water heater or marine toilet, so I may be a bit lighter than other CD25's. I get on average, 2.5-2.8 nmpg (nautical), bad conditions 2.2, great conditions 3.0 (very rare). 2-4 people on board, almost always with overnight gear, fresh water, fishing gear, etc.