With the original seats, no way. With the new seats, sure thing.
Solo, it would be tiring but still pretty doable in our 19 within the sailing boats time of 4+days. Cruising at 15 knots in decent water, 11 in bad water, and 6 in worse water. Conditions bad enough to keep off the water could be a factor but our little dorys can take a lot. Pack on the gas cans and go. This trip might be predictably smoother than our Alaska Brats commonly fish in for fun.
With another driver, a boat could push on more continuously and make it a tree day trip even at our boats slow planing cruise speed.
A 23-25-26 or tomcat could do better yet with higher sustained speeds.
The record from Seattle to Ketchikan in an outboard powered boat (twin 300s) is under 12 hours. The lead boat in this race took nearly that long to cross from Port Townsend to Victoria.
We ran our 25 from Telegraph Cove south to Comox (125 miles) in under 5 hours with a toddler playing happily the whole way and arrived with ample time for grocery shopping, dock walking, playground time, and dinner out and toddler bedtime. That 25 did cover some water.
Motors are in a different league so they are not allowed.
Greg