I played collsion sports back when I was stupid (I'd do it again!), and now I hurt, sometimes debilitatingly so, but I need to run a boat regardless, sometimes through whitewater and very very very challenging conditions. I have literally been to the neurologist before a bigger trip asking if it was okay for me to go and uttering the phrase "I'm just worried that my head is going to come flying off if i hit a big standing wave or something" in all seriousness. This condition has caused one of my arms to be generally useless on occasion, so I feel like this is something I can weigh in on with some real-world advice. If I'm running the boat injured, I set it up for that before I go and try to load it up simply.
1. Do you have autopilot? If not, that would be a major advantage for you.
2. Get your engines serviced by a pro preseason and attend to any issues. Change your water pump, lower unit, and engine oil. In other words, do everything reasonable to mitigate a possible mechanical breakdowns.
3. I may prep lines and keep them looped through themselves onto a grab bar or similar on deck instead of stowing coiled to themselves. I coil the line into a loop and put it behind the bar then pull the top half around the bar and through the bottom so I can grab it and go one-handed. This makes the deck a little more cluttered, but I don't need to open a hatch and then wade through gear to get at a line. No problem two handed, but not as easy one handed. I need lines regularly, and could easily need one in a pinch, and I give up a little deck space, but have lines when needed.
4. bring extra stuff: you plan to go out in fair weather, but be ready for bad weather, and being laid up, plan to wait out the nasty stuff, so extra food, a change of clothes, a full compliment of water, and full fuel tanks before you head out. If things get snotty, find someplace quiet and relax til it blows over. I have survival kits that go with me everywhere. They fit in my pocket and help me to live through the unplanned. I also have comfort kits which are large dry bags full of good stuff like tents, sleeping bags, MREs, playing cards, etc etc etc. But that's on a jet boat, you can just load this into your CDory if it's not already there.
5. bring less stuff: If you have downriggers, pot pullers, fishing poles etc on board, you might want to get rid of them. If I were in your spot, and had them, I'd use them, and they are two-handed gizmos. So I would come back to port more injured than when I left, and I'd be considered a dope in my own home, and my Admiral would probably keep me shoreside until I was ready for active duty.