A 16' Cruiser would probably not have enough fuel capacity to do the Inside Passage safely.
Using the rule of 1/3s (1/3 out, 1/3 back, 1/3 reserve), I estimated a safe radius of about 35-40 nm under ideal conditions. It would be sufficient for a short run from Juneau to Hoonah (70 nm) for a refuel stop. A run from Juneau to Haines (80 nm) is feasible if launching from Amalga Harbor or Echo Cove.
The transom of the boat is pretty well loaded down, so spare fuel would have to be moved forward to balance the load. You also have to factor in provisions, emergency gear & the like.
With both me & my wife on board, fuel economy dropped about 1nm/gal. Going solo, fuel economy was noticeably better. Getting on plane was also a lot easier.
A 19' Angler would probably be the smallest C-Dory I'd recommend for extended travel (Glacier Bay, Elfin Cove, Pelican & beyond)
Brian