Here is a new report describing V cholerae (several species in the Vibrio genus) non serotype O1 and O139 outbreak in South Carolina linked to seafood. We investigated an outbreak a couple years ago and toxigenic V cholerae serotype O75 was the causative agent. CDC did the typing and toxin testing and expect they will perform testing on these isolates
CHOLERA - USA: (SOUTH CAROLINA) PROBABLE NON-O1, NON-O139
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A ProMED-mail post
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Date: Wed 16 Oct 2013
Source: FOX Carolina [edited]
<http://www.foxcarolina.com/story/23711212/dhec-shellfish-illness-sickens-sc-residents>
Officials are warning the public after 3 people in South Carolina
became ill from eating shellfish. The South Carolina Department of
Health and Environmental Control [DHEC] said on Wednesday, 16 Oct
2013, that the 3 people have confirmed cases. DHEC said the bacterium
causes gastroenteritis, not cholera.
"We are working with the FDA and many partners to identify the source
of the contaminated shellfish," said Linda Bell, MD and state
epidemiologist. "We are informing healthcare providers of the
situation and will continue to monitor the state for additional
cases."
DHEC said there is no evidence the contaminated shellfish originated
in South Carolina waters.
They said the symptoms of _Vibrio cholerae_ include nausea, vomiting
and diarrhea that begin from a few hours to up to 5 days after
consumption of raw shellfish. The infection is usually mild or without
symptoms, but can occasionally be severe. In severe cases, an infected
person may experience profuse watery diarrhea and vomiting that can
cause dehydration and shock, DHEC said.
"The elderly, young and immunocompromised are particularly at risk of
developing illness from consuming raw shellfish," said Bell. "The best
way to protect yourself and your family from getting ill is to
thoroughly cook all shellfish before eating."
[Byline: Joseph Pereira]
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[Given the statement that the infections were "not cholera," the
organisms identified in the SC cases were likely non-epidemic strains
of _Vibrio cholerae_ that were non-O1 and non O-139 isolates. Overall,
non-O1, non-O139 strains of _V. cholerae_ tend to (but not always)
cause milder gastrointestinal illness and also can have bacteremic,
non-diarrhea presentations.
In almost all cases, non-O1, non-O139 _V. cholerae_ isolates do not
possess the genes for either cholera toxin or the toxin-coregulated
pilus (TCP). Yet, some isolates can cause substantial diarrhea (1-4).
The type III secretion system (TTSS) is a mechanism for Gram negative
bacilli to introduce effector proteins into host cell cytoplasm (5).
It has been reported that a functional TTSS is required for at least
some non-O1, non-O139 isolates to induce diarrhea in an animal model
associated with small bowel damage and production of proinflammatory
cytokines (6). In addition, TTSS contributes to virulence even in the
presence of cholera toxin and TCP (6).
References:
1. Bhattacharya MK, Dutta D, Bhattacharya SK, et al. Association of
disease approximating cholera caused by _Vibrio cholerae_ of
serogroups other than O1 and O139. Epidemiol Infect. 1998; 120: 1-5.
2. Sharma C, Thungapathra M, Ghosh A, et al. Molecular analysis of
non-O1, non-O139 _Vibrio cholerae_ associated with an unusual upsurge
in the incidence of cholera-like disease in Calcutta, India. J Clin
Microbiol. 1998; 36: 756-763.
3. Bidinost C, Saka HA, Aliendro O, et al. Virulence factors of
non-O1, non-O139 _Vibrio cholerae_ in Cordoba, Argentina. Rev Argent
Microbiol. 2004; 36: 158-163.
4. Chatterjee SC, Ghosh K, Raychoudhuri A, et al. Incidence, virulence
factors, and clonality among clinical strains of non-O1, non-O139
_Vibrio cholerae_ isolates from hospitalized diarrheal patients in
Kolkata, India. J Clin Microbiol. 2009; 47: 1087-1095.
5. Gatan JE, Colimer A. Type III secretion machines: bacterial devices
for protein delivery into host cells. Science 1999: 284: 1322-1328.
6. Shin OS, Tam VC, Suzuki M, et al. Type III secretion is essential
for the rapidly fatal diarrheal disease caused by non-O1, non-O139
_Vibrio cholerae_. mBio 2(3): e00106-11.doi:0.01128/mBio.00106-11.
- Mod.LL
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[see also:
2011
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Cholera - USA (05): (NY) non-O1, non-O139 20110706.2046
Cholera - USA: (NY): RFI 20110616.1840
Cholera O75 - USA: (FL) raw oysters, warning 20110511.1443
Cholera - USA (03): (NY) ex Dominican Rep. banquet 20110208.0429
Cholera - USA (02): (MA) ex Dominican Rep. banquet 20110130.0364
Cholera - USA: (MA) ex Dominican Rep., banquet 20110127.0326
2010
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Cholera - Haiti (21): USA (FL) 2010