The "average car" drives about 10,000 miles a year--figure in 5 years 50,000 miles--sure there is a huge variance.
Look at the number of "Road Gators" on the highway. These are usually tread separation from "18 wheeler" trailer tires. Yes some of these have been re-treaded, or used past their useful tread life. But if you look at the better freight companies, their tires will be in good condition--and changed regularly.
In an RV, the most dangerous tire blow out is on the steer axle. It is also on a trailer of any sort. A lot depends on the type of tow vehicle and its weight--but a blown tire on a single axle trailer, can easily lead to serious problems, including flipping the trailer.
As Captain Charlie about trailer tires. When I sold the Tom Cat to him, I pointed out that the trailer tires were at 5 years by date (not by use)--they only had about 300 miles on them and looked like new. I proposed that we change them, and split the cost. He had two blow out on the trip to VA. The trailer was rated at over 13,000 lbs.
The RV world has pretty much adopted this 5 to 7 year mantra, to replace the tires. It is not new. You hear more about it now because of the internet and communication. I followed that rule for the 60+ years I have been RVing and towing trailers.
One of the reasons that both RV's and boat trailers tend to degrade faster, is that when a tire is "exercised" there is working of the rubber
The anti-aging chemicals used in the rubber compounds are more effective when the tire is exercised. The repeated stretching of the rubber compound actually helps deter cracks from forming. The tires used on vehicles that are driven infrequently, or accumulate low annual mileage are more likely to experience cracking because long periods of parking or storage interrupt "working" the rubber.
From the Tire Rack. Also when sitting in one place there is a "flat" place on the tire.
This year, I replaced the tires on the original trailer my current Tom Cat came on. One of the tires was 3 years old--and developed an aneurysm, just sitting in our yard--and it was the side of the trailer which never got direct sunlight.
It is best to cover the tires with a tire cover. This keeps UV, acid rain, other chemicals etc off the tire. We do this for the RV. (and should do it for the boat trailers, even though they are in the shade most of the time.