The "Patch" is a prescription medication called Transderm scop. It contains the medication scopolomine, an anticholinergic. The patch should be applied at least 4 hours before traveling, and can be worn for up to 3 days. It does have a fair amount of side effects, including dry mouth, drowsiness, blurred vision, difficulty urinating, etc. Dramamine is an antihistamine with significant anticholinergic properties. It has a similar side effect profile (drowsiness, blurred vision, dry mouth, difficulty urinating, etc). The combination of the two might be too much for many people. It would sure prevent motion sickness, but you might not be able to stand up. I recently started using the electric wristband "reliefband". I thought it sounded kind of gimmicky, and was skeptical at first, but after putting it to use in some pretty rough water, it really worked for me. Unlike the non-electrical device (seaband), the reliefband is FDA approved, which means that it has been tested in clinical trials, and shown to actually work. It is actually a prescription item when used for chemotherapy, or non-motion sickness nausea and vomiting, but is over the counter for motion sickness. It causes a funny nerve stimulation sensation in the nerves of your wrist and hand, which some people might have a hard time getting used to, but it wasn't really uncomfortable. It really worked for me, and didn't have any side effects (other than the tingling sensation in my hand and fingers). It's expensive, but if you are prone to seasickness like I am, it's certainly worth the price.