Your wife sounds like me! If it moves, I can puke on, or in it. I can feel the first effects of motion sickness on a floating dock or a tall building, and it is almost immediate. I can say without exaggeration, that if I had the strength to roll overboard I would have, preferring death to how I felt.
I've tried all of the aforementioned and I agree, they may work for your wife. What has worked for me has been Scopolamene (the patch). It requires a prescription but I've never been sick on it. The most noticeable side affect for me has been the dry mouth and I've then prescribed beer to cure that.
The zero side affect cure for me though has been to be the operator. I haven't gotten the least bit sick if I get to drive, all the time. I can't explain it.., it's just so for me. Let me re-state the severity of my affliction. I've gotten sick on a teeter-totter so if this describes your wife then that may be a solution for her too.
Lastly, I used to work off-shore on a floating oil rig for weeks at a time. I suffered through the first 2-3 days of my tour on regular dramamine, then quit taking it. Apparently my body had gotten used to the motion by then and there was no sickness after that for the balance of that tour. The drill had to be repeated for each new tour however. If you're planning a trip of any length, this may work for her too.
Best of luck,
Bill