As was pointed out above, in the 16-foot size, the Cruiser has a V-berth for sleeping, whereas the Angler does not (you'd have to improvise in the cockpit).
Once you get longer than the 16' size, all of the versions have a V-berth (to my knowledge), and the typical variation then is that the cabin (aft of the V-berth) is abbreviated on the Angler - but you get a longer cockpit. On the Cruiser you get more cabin, but less cockpit.
Another point is that the 16 doesn't have an aft bulkhead. Unless you modify it, you would either have no division (just open) or a Sunbrella "wall" separating cabin and cockpit. I think on the 19 it could go either way (but not sure on that). On the 22 there are a very few with no aft bulkhead, but the vast majority (Cruiser or Angler) have the same bulkhead/cabin door.
I am more of a cruiser, but I still strongly considered the 22 Angler (I have a 22 Cruiser). Reason is that I could see "living" in the cockpit (with a good camperback) and then just having more elbow room all the way around vs. the slight "miniaturization" you get with the Cruiser's cabin/cockpit combo. Then too, I would have had more flexibility for snorkeling or diving (although no 22 is a great dive boat, really).
I'm not as familiar with the Anglers, but I think that at least in the 22 there were a couple of options for the interior. One had a small dinette and maybe one didn't (?).
There is also the Classic 22, which may be a good option if you are on a budget. Those were built prior to 1987, and look quite a bit like a "modern" 22 Angler, but have a flatter bottom and other variations (nowadays the Angler and Cruiser share a hull that is slightly more V-shaped).
Welcome to the forum,
Sunbeam