I once read that the reason the helm is typically located on the Starboard side of small boats is to counterbalance the torque caused by the prop rotation. But considering all the other variables such as passengers, gear, trim tabs, kicker motors, batteries, etc, I would see no reason it can't be done aside from possibly a limited prop selection, if counter-rotating props are sold in the higher pitches needed for twins (have no idea if that is true or not, as I've never had to shop for such props).
-Mike