My CD 22 has twin Suzuki's. My boat mechanic says that the power head on the motor when fully tilted places the center of gravity of the motor on or slightly ahead of the motor mounting bracket such that the "bouncing" moment is vertical over the bracket. Not cantilevered over the back end, and therefore will not induce twisting motions on the motor bracket. On the other hand, with the motors down, the CG is clearly aft of the stern, and will induce a twisting or bending load on the stern when you hit bumps.
That is what he says, and he's got 40 year of experience.
I had a small trailerable houseboat that had a heavy merc 90 on an extended motor mount. The mount was a good two feet aft of the stern of the boat and the motor hung off of that. There was a huge moment arm hanging off that stern and it always bothered me, but the boat was towed thousands of miles that way. I still stowed the motor in the up position so's not to strain the mounting bits that were part of the motor itself.
Also, to finish off this tome, my mechanic says that if a stern and motor can't handle highway bouncing around, then it is going to be a weak design under motoring in heavy seas as well.
So, you pays yer money and you takes yer chances.