There is an abundance of info on the site about this already, and please feel free to discuss your questions on this thread instead of in a PM. Everyone is interested and it's kind of the point of all of this.
The jury is in on permatrim, and it's widely accepted as a great upgrade for anyone. It will very simply increase your boat's responsiveness to it's tilt/trim allowing you greater control of your ride.
CDories are very very very very very sensitive to trim, and your boat's ride will be impacted greatly if you are able to trim the bow down when heading into chop, or trim the bow waaay up when riding in swells or a following sea. Trim tabs are a must, but they can be used for balancing an unevenly loaded boat even more if you have a permatrim doing the heavy lifting on the bow adjustments.
One thing to be conscious of if you are operating both, is to avoid getting the ride just right by having the permatrim and the trim tabs fighting each other. It can sap your efficiency. This can be helpful in some, but very few, situations, but overall can leave you with less ability to control your boat in addition to added fuel cost and reduced range.
So, don't be nervous about those little holes. If you want more bow up/down control, drill those holes and install that permatrim!!