Mike,
What I generally do is make the "major" adjustment to the engine position using the motor's trim feature and the trim tabs for the minor (precise) adjustments. For now, leave the trim tabs in the fully retracted position; you'll get to them later. Play with the motor trim a bit, and with some experimenting you will find what seems to be the best combination of engine trim and resulting speed (which will vary with loads and sea conditions). To begin, you will probably want to experiment with the engine trim adjustment at about it's neutral setting. Remember - trimming the motor 'down will help you get on plane, but probably not your most advantageous position. Again ... experiment, experiment, experiment. I even found that it's good to make some notes - to help me remember the next time "what seemed to work best."
Once you're comfortable with engine trim move on to experimenting with the trim tabs. Set up the engine in the optimum configuration and now, begin adding-in some trim(tab). For now, use both trim tabs together. Add a little, then add some more. Notice how the pitch attitude of the boat changes. More and more trim tab will bring the bow down - you'll see/feel the difference. (Be a little careful if you add full trim tabs at high(er) speed; you could bring the bow down farther than you were expecting!
If you have a fuel meter, watch the gph and boat speed. with some playing around you will find that "sweet spot" that yields the best speed at the lowest RPM with only the (least) necessary amount of trim tabs. (Remember - on plane the trim tabs themselves will induce increasingly inefficient 'drag, so this is a case where less-is-better.)
As you become more comfortable with your trim tabs you will find them to be very useful. If your boat is unevenly loaded you can correct it (somewhat) by using different tabs setting on port or starboard.
Best,
Casey&Mary